Anti-Tumor Necrosis Factor- Therapy Reduces Aortic Inflammation and Stiffness in Patients with Rheumatoid Arthritis Running title: Mäki-Petäjä et al.; Aortic inflammation in rheumatoid arthritis
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Address for r r Co Co Corr rr rres es spo po p nd nd n en en enc c ce: Abstract: Background—Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with
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Anti-tumor necrosis factor-α therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis.
BACKGROUND Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with increased cardiovascular risk. This is not fully explained by traditional risk factors, but direct vascular inflammation and aortic stiffening may play a role. We hypothesized that patients with RA exhibit aortic inflammation, which can be reversed with anti-tumor necrosis factor-α therapy and correlates w...
متن کاملImaging Anti-Tumor Necrosis Factor- Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis
Background—Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with increased cardiovascular risk. This is not fully explained by traditional risk factors, but direct vascular inflammation and aortic stiffening may play a role. We hypothesized that patients with RA exhibit aortic inflammation, which can be reversed with anti-tumor necrosis factortherapy and correlates with...
متن کاملUnravelling the phenotype of cardiovascular inflammation with magnetic resonance imaging: detecting the change with anti-TNF treatment in patients with rheumatoid arthritis
Background Excess of cardiovascular (CV) morbidity and mortality in RA patients is not fully explained by traditional CV risk factors. Evidence suggests the presence of inflammation-induced vascular and myocardial injury and dysfunction, leading to premature atherosclerosis and heart failure. Aortic stiffness, an independent predictor of cardiac events and a marker of pulsatile LV afterload, im...
متن کاملEffect of TNF-α Blockade in Gingival Crevicular Fluid on Periodontal Condition of Patients with Rheumatoid Arthritis
Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. Method: The periodontal statuses of 3...
متن کاملEffects of 6 months of abatacept treatment on aortic stiffness in patients with rheumatoid arthritis
BACKGROUND Systemic inflammation plays an important role in the increased cardiac risk observed in rheumatoid arthritis (RA). Effective control of inflammation and disease activity may be of benefit in reducing cardiovascular risk in RA patients. OBJECTIVE Our study was conducted in patients with active RA to investigate the effects of 24-week abatacept treatment on aortic stiffness measured ...
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تاریخ انتشار 2012